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Our in vitro success counsel that EAM-2201 should be examined when it comes to likely in vivo pharmacokinetic drug–drug interactions due to time-dependent inhibition of CYP2C8, CYP2C9, CYP2C19 and CYP3A4 functions and competitive inhibition of UGT1A3 action.
EAM-2201 was incubated with human hepatocytes for 3 h within a CO2 incubator and also the metabolites of EAM-2201 were being made. The human liver specimen was homogenized and the metabolites ended up extracted. The urine specimen was hydrolyzed initial with β-glucuronidase as well as metabolites had been extracted.
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